HIV-TB coinfection impairs CD8+T-cell differentiation and function while dehydroepiandrosterone improves cytotoxic antitubercular immune responses
نویسندگان
چکیده
منابع مشابه
TB and HIV Coinfection: Current Trends, Diagnosis and Treatment Update
17 the impact that hiv has on the pathogenesis of tuberculosis (tb) is clear. It is one of the most important risk factors associated with an increased risk of latent tb infection (ltbi) progressing to active tb disease. hiv-infected people have an annual risk of 5% to 15% of developing active tb once infected (Rieder, 1999). tb is the most common opportunistic infection in people living with h...
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BACKGROUND Host effector mechanism against Mycobacterium tuberculosis (Mtb) infection is dependent on innate immune response by macrophages and neutrophils and the alterations in balanced adaptive immunity. Coordinated release of cytolytic effector molecules from NK cells and effector T cells and the subsequent granule-associated killing of infected cells have been documented; however, their ro...
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We propose a population model for TB-HIV/AIDS coinfection transmission dynamics, which considers antiretroviral therapy for HIV infection and treatments for latent and active tuberculosis. The HIV-only and TB-only sub-models are analyzed separately, as well as the TB-HIV/AIDS full model. The respective basic reproduction numbers are computed, equilibria and stability are studied. Optimal contro...
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In this thesis, a mathematical model describing the interaction between HIV and TB in the presence of TB superinfection is presented. The model takes into account two strains of Mycobacterium tuberculosis (MTB), where one strain is drug-sensitive and the other is resistant to at least one of the first-line anti-tuberculosis drugs. The impact of TB superinfection on the incidence and prevalence ...
متن کاملCoinfection with herpes simplex virus type 2 is associated with reduced HIV-specific T cell responses and systemic immune activation.
BACKGROUND Chronic coinfection with herpes simplex virus type 2 (HSV-2) and human immunodeficiency virus (HIV) has been associated with an increased HIV viral load and more rapid disease progression, perhaps related to HSV-2-associated alterations in host immunity. METHODS Studies were nested within (1) a cross-sectional study of men coinfected with HIV and HSV-2 and (2) women not infected wi...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2015
ISSN: 0014-2980
DOI: 10.1002/eji.201545545